Procedure & Treatment Library

Fentanyl Oral Transmucosal

Why is this Medication Prescribed?

Fentanyl oral transmucosal is used to treat breakthrough pain that is uncontrolled by a regularly prescribed narcotic pain medication in people with chronic cancer pain. Fentanyl is a narcotic (opioid) analgesic. It works to treat pain by changing the way the brain and nervous system respond to pain.

How Should this Medication be Used?

  1. Check the blister package and the handle of the fentanyl oral transmucosal unit to make sure the unit contains the dose of medication you have been prescribed.
  2. Use scissors to cut open the blister package containing fentanyl oral transmucosal, and remove the medication unit. Do not use the medication unit if the blister package has been damaged or opened before you are ready to use it, or if the medication is expired. If the medication is expired or damaged, call your pharmacist.
  3. Fentanyl oral transmucosal comes as a solid dosage unit on a handle to place in the mouth between the cheek and gum.
  4. Place fentanyl oral transmucosal in your mouth, between your cheek and lower gum, and actively suck on the medication unit.
  5. Move the unit around in your mouth, from one side to the other, using the handle. Twirl the handle often. Do not eat or drink anything while using fentanyl oral transmucosal. Do not bite or chew fentanyl oral transmucosal.
  6. Finish the fentanyl oral transmucosal in about 15 minutes.
Image by Crohnie [GFDL ( or CC-BY-SA-3.0 (], via Wikimedia Common

How to Dispose of Fentanyl Oral Transmucosal

Important Advice for Patients

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