Ambroxol for neuropathic pain: hiding in plain sight?

Ambroxol is a multifaceted drug with primarily mucoactive and secretolytic actions, along with anti-inflammatory, antioxidant, and local anaesthetic properties. In more recent years, ambroxol has gained interest for its potential usefulness in treating neuropathic pain.

Long-Term Outcomes of Restorative Neurostimulation in Patients With Refractory Chronic Low Back Pain Secondary to Multifidus Dysfunction: Two-Year Results of the ReActiv8-B Pivotal Trial

This study aimed to evaluate the two-year effectiveness of this restorative neurostimulator in patients with disabling CLBP secondary to multifidus muscle dysfunction and no indications for spine surgery.

Three-Year Durability of Restorative Neurostimulation Effectiveness in Patients With Chronic Low Back Pain and Multifidus Muscle Dysfunction.

Neuromodulation. 2023; 26(1): 98-108.

Gabapentin – Friend or foe?

Gabapentin is a recommended first-line agent for treating neuropathic pain; however, its efficacy rate is reportedly low, and the risk of adverse events is high. Pain Practice. 2023; 23(1): 63-69.

Holistic Treatment Response: An International Expert Panel Definition and Criteria for a New Paradigm in the Assessment of Clinical Outcomes of Spinal Cord Stimulation

The aim of this article is to add to a framework started by IMMPACT for assessing the wider health impact of treatment with SCS for people with chronic pain, a ”holistic treatment response”.

Educational Curriculum for Peripheral Nerve Stimulation Developed by the North American Neuromodulation Society.


Novel immune biomarkers in complex regional pain syndrome

In this study, we found evidence of reduced levels of an important anti-inflammatory molecule known as interleukin-37 in CRPS patients, as well as involvement of the immune-activated Kynurenine pathway, which may be linked to pain in CRPS.

Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome.

Journal of Neuroinflammation

A new hypothesis for the pathophysiology of complex regional pain syndrome.

Medical Hypotheses 119: 41-53

Cervical spinal cord stimulation for the treatment of essential tremor.

BMJ Case Reports

Meaningful relief with flurbiprofen 8.75 mg spray in patients with sore throat due to upper respiratory tract infection.

Pain Management 8(2): 79-83

New Therapy for Refractory Chronic Mechanical Low Back Pain-Restorative Neurostimulation to Activate the Lumbar Multifidus: One Year Results of a Prospective Multicenter Clinical Trial.

Neuromodulation 21(1): 48-55

Effective Relief of Pain and Associated Symptoms With Closed-Loop Spinal Cord Stimulation System: Preliminary Results of the Avalon Study.

Neuromodulation 21(1): 38-47

Muscle Control and Non-specific Chronic Low Back Pain.

Neuromodulation 21(1): 1-9

The physiological effects of slow breathing in the healthy human.

Breathe 13(4): 298-309

Pain relief of sore throat with a new anti-inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double-blind, placebo-controlled, international phase III study.

International Journal of Clinical Practice 71(9): e12961

Comment on "Probable Tapentadol-Associated Serotonin Syndrome after Overdose".

Hospital Pharmacy 52(4)

Targeting the cause, not just the symptoms: A new treatment for chronic low back pain - results of the ReActiv8-A trial.

Journal of Science and Medicine in Sport 20(S1): e15

The Neurostimulation Appropriateness Consensus Committee (NACC) Recommendations for Infection Prevention and Management.

Neuromodulation 20(1): 31-50

The Neurostimulation Appropriateness Consensus Committee (NACC): Recommendations on Bleeding and Coagulation Management in Neurostimulation Devices.

Neuromodulation 20(2): 133-154

The Polyanalgesic Consensus Conference (PACC): Recommendations for Trialing of Intrathecal Drug Delivery Infusion Therapy.

Neuromodulation 20(2): 133-154

Chronic abdominal wall pain.

Journal of Clinical Gastroenterology

Effectiveness of PRP in the treatment of tendinopathy: letter to the editor.

The American Journal of Sports Medicine 44(10): NP52-NP53

Effectiveness and tolerability of tapentadol sustained release in the Australian setting.

Journal of Opioid Management 12(3): 187-196

High Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Chronic Pain: 6-Month Australian Clinical Experience.

Pain Physician 19(4): 267-280

Efficacy of flurbiprofen 8.75 mg spray in patients with sore throat due to an upper respiratory tract infection: A randomised controlled trial.

The European Journal of General Practice 30: 1-8

Results From the Partnership for Advancement in Neuromodulation Registry: A 24-Month Follow-Up.

Neuromodulation 19(2): 179-187

Comment on "In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain" by Vasudeva et al., J. Neuroimmunol. 2015 June; 283:3-49.

Journal of Neuroimmunology 286: 77-78

A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients.

Pain Practice 16(1): E14-20

Improved Pain Relief With Burst Spinal Cord Stimulation for Two Weeks in Patients Using Tonic Stimulation: Results From a Small Clinical Study.

Neuromodulation 18(5): 361-366.

(366) Efficacy of flurbiprofen 8.75 mg spray in patients with relatively severe sore throat symptoms.

The Journal of Pain 16(4): S67

Thoracic Spinal Cord Stimulation for Heart Failure as a Restorative Treatment (SCS HEART study): first-in-man experience.

Heart Rhythm 12(3): 588-595

10-kHz High-Frequency SCS Therapy: A Clinical Summary.

Pain Medicine 16(5): 934-942

Lack of body positional effects on paresthesias when stimulating the dorsal root ganglion (DRG) in the treatment of chronic pain.

Neuromodulation 18(1): 50-57; discussion 57

One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain.

Neuromodulation 18(1): 41-48; discussion 48-49

The appropriate use of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: the Neuromodulation Appropriateness Consensus Committee.

Neuromodulation 17(6): 515-550; discussion 550

Re: Freeman BJ, Ludbrook GL, Hall S, et al. Randomized, double-blind, placebo-controlled, trial of transforaminal epidural etanercept for the treatment of symptomatic lumbar disc herniation. Spine 2013;38:1986-94.

Spine (Phila Pa 1976) 39(15): 1262

International Neuromodulation Society Critical Assessment: Guideline Review of Implantable Neurostimulation Devices.


Interim Results From the Partnership for Advancement in Neuromodulation Pain Registry.

Neuromodulation 17(7): 656-664

Stimulation of Dorsal Root Ganglia for the Management of Complex Regional Pain Syndrome: A Prospective Case Series.

Pain Practice 15(3): 208-216

A multicenter, prospective trial to assess the safety and performance of the spinal modulation dorsal root ganglion neurostimulator system in the treatment of chronic pain.

Neuromodulation 16(5): 471-482; discussion 482

Flurbiprofen microgranules for relief of sore throat: a randomised, double-blind trial.

British Journal of General Practice 63(607): e149-155

Patient preference for sustained-release versus standard paracetamol (acetaminophen): a multicentre, randomized, open-label, two-way crossover study in subjects with knee osteoarthritis.

Journal of International Medical Research 37(5): 1321-1335

Re: Complex regional pain syndrome after infliximab infusion.

Journal of Pain and Symptom Management 37(3): e9-10

Chronic Non-Malignant Pain.

Australian Doctor 21(March): 25-32

A clinical snapshot of transdermal buprenorphine in pain management.

European Journal of Pain Supplements 1(1): 74-77

Anti-hyperalgesia properties of buprenorphine.

Pain 122(1-2): 216; author reply 216

Recovery from bispectral index-guided anaesthesia.

Anaesthesia and Intensive Care 34(1): 127; author reply 127

Letter to the editor regarding Reig et al., Thermocoagulation of the ganglion impar of Walther: description of a modified approach. Preliminary results in chronic, nononcological pain. Pain Practice 2005;5(2):103-110.

Pain Practice 5(4): 367

Inadvertent subdural spread complicating cervical epidural steroid injection - Reply

Anaesthesia and Intensive Care 32(1): 145-146

Dilutional acidosis: a nonentity?

Anesthesiology 87(4): 1010-1011; Author Reply 1013-1014

Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a debilitating condition where trauma to a limb results in devastating persistent pain that is disproportionate to the initial injury.

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